HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 7-Chloro-6-((S)-2-methyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenyl-propyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 6-[(2S)-2-methylpyrrolidine-1-carbonyl]-N-[(1R)-1-phenylpropyl]-1H,3H,4H-pyrrolo[2,1-c][1,4]oxazine-8-carboxamide | HCID 71696125 | — |
| Product | 7-Chloro-6-((S)-2-methyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenyl-propyl)-amide | HCID 89734092 | — |
Reaction Steps
The compound was prepared from 6-((S)-2-methyl-pyrrolidine-1-carbonyl)-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-8-carboxylic acid ((R)-1-phenyl-propyl)-amide (Comp. No. 16a) and N-chloro-succinimide in analogy to the synthesis of comp. no. 16ru. LC/MS (method 3): Rt=1.86 min; m/z=430.22 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284333B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-ff9c5bb74f92478a9fb7389354e6b94c |
| Source note | uspto-grants-2016_03 |