HCID 71185318, compound → HCID 71185457, compound

Participants

Reaction Conditions

Reaction Steps

A solution of CeCl3 (1.51 equiv.) in THF (75 ml) was stirred at room temp for 1 hour. The suspension was cooled down to −78° C., MeLi (1.50 equiv., 1.46M in Et2O) was slowly added over 10 minutes, followed by the addition of a solution of (2a) (20.31 mmol) in THF (15 ml). After 30 minutes, the mixture was allowed to warm to 0° C. and quenched by adding NH4Cl and ice. The mixture was extracted with Et2O and the organic layers were washed with water, saturated bicarbonate solution, and brine. After drying with MgSO4, the solution was concentrated and distilled (125° C., 0.1 mbar). Yield 99%.

Provenance & Evidence