Ethylene Glycol → HCID 87376001, compound

Participants

Reaction Conditions

Reaction Steps

Lauric acid (9.0 g; 44.9 mmol; 1.0 equiv) was combined with poly (ethylene glycol) methyl ether (25.8 g; 44.9 mmol; 1.0 equiv) having an average molecular weight of 574 (available from Sigma Aldrich) in a 100-mL 3 neck round bottom flask equipped with a magnetic stir bar. Immobilized lipase Novozym®435 was added to the flask in an amount of 1.00 grams (2.9 wt % based on the total weight of starting materials). The mixture was stirred and heated to 65° C. and purged with a subsurface stream of nitrogen at a rate of 200 mL/min. After 24 hours a final sample was removed and analyzed by HPLC to determine conversion of poly(ethylene glycol) methyl ether and lauric acid to PEG-12 methyl ether dilaurate. Conversion was 100%.

Provenance & Evidence