Tetramethyltin → HCID 71268198, compound

Participants

Reaction Steps

Tetramethyltin (287 μL, 2 mmol) was added to a DMF (2 mL) solution containing 1-(2-deoxy-β-D-ribofuranosyl)-4-iodo-2-nitropyrrole (142 mg, 0.4 mmol), bis(triphenylphosphine)palladium(II) dichloride (14 mg, 0.02 mmol), and triphenylarsine (12 mg, 0.04 mmol), followed by reaction at 60° C. for 2 days. The reaction solution was separated between ethyl acetate (50 mL) and water (50 mL). The organic layer was concentrated and purified by HPLC to yield 1-(2-deoxy-β-D-ribofuranosyl)-4-methyl-2-nitropyrrole (15 mg, 0.06 mmol, 15%).

Provenance & Evidence