Acetic Acid → HCID 118006223, compound

Participants

Reaction Conditions

Reaction Steps

A mixture containing methyl 3-oxopentanoate (2.2 g, 17 mmol), 4-(1H-pyrazol-1-yl)benzaldehyde (2.5 g, 14 mmol), piperidine (0.3 mL, 3.0 mmol), and acetic acid (0.16 mL, 2.8 mmol) in benzene (70 mL) was heated to 90° C. with removal of water (Dean-Stark trap). After 4 hours, the mixture was cooled to 23° C. and then concentrated to provide the title compound. The residue (mixture of alkene isomers) was taken onto the next step without further purification.

Provenance & Evidence