HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Fluorobenzoyl)pyridine → (3-(4-(1H-Pyrazol-1-yl)benzyl)-2,4-dichloroquinolin-6-yl)(3-fluorophenyl)(pyridin-3-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Fluorobenzoyl)pyridine | HCID 12930029 | — |
| Reactant | 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline | HCID 86715594 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | (3-(4-(1H-Pyrazol-1-yl)benzyl)-2,4-dichloroquinolin-6-yl)(3-fluorophenyl)(pyridin-3-yl)methanol | HCID 74220811 | — |
Reaction Steps
The title compound was prepared analogously to the method in Intermediate 37 using (3-fluorophenyl)(pyridin-3-yl)methanone (Intermediate 34: step b) in place of (4-chlorophenyl)(pyridin-3-yl)methanone, except that 1.2 equivalents of Intermediate 34: step b and 1.1 equivalents of n-BuLi were used relative to 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloroquinoline (Intermediate 3: step c).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284308B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-12d2d999736f4fdbbbf4ec853a14fbc2 |
| Source note | uspto-grants-2016_03 |