5-(4-Methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(4-Methylsulfonylbenzyl)malonic acid

HRID 926510Notes

Reaction equation

HRID 926510 reaction equation
S1C(CC2C(=O)OC(C)(C)OC2=O)=CC2C=CC=CC1=2.S1C(CC(C(O)=O)C(O)=O)=CC2C=CC=CC1=2.[CH3:38][S:39]([C:42]1[CH:58]=[CH:57][C:45]([CH2:46][CH:47]2[C:52](=[O:53])[O:51]C(C)(C)[O:49][C:48]2=[O:56])=[CH:44][CH:43]=1)(=[O:41])=[O:40]>>[CH3:38][S:39]([C:42]1[CH:43]=[CH:44][C:45]([CH2:46][CH:47]([C:48]([OH:56])=[O:49])[C:52]([OH:53])=[O:51])=[CH:57][CH:58]=1)(=[O:40])=[O:41]

Participants

4

Reactant 3

HCID 867155855-(4-Methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 867155895-(Benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 867155902-(Benzo[b]thiophen-2-ylmethyl)malonic acid3×

Product 1

HCID 867155862-(4-Methylsulfonylbenzyl)malonic acid

Procedure

The title compound was prepared by substituting 5-(benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 39: step a) with 5-(4-methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 41: step a) then following the procedure described for the preparation of 2-(benzo[b]thiophen-2-ylmethyl)malonic acid (Intermediate 39: step b).

Sources & evidence

ORD record
ord-7b63311b572c4730bc2577033bdfb1fa
Source dataset
uspto-grants-2016_03
Patent number
US09284308B2

Reaction notes

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