反应详情

温度

105 °C

A mixture of (2,4-dichloro-3-(4-(methylsulfonyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanone (1 g, 2.085 mmol, Intermediate 41: step c) and solid sodium methoxide (0.56 g, 10.42 mmol) in toluene (10 mL) was heated in a sealed tube at 105° C. for 12 hours, cooled to room temperature, diluted with DCM and the resulting suspension filtered through Celite®, rinsing several times with DCM. The solvents were removed under reduced pressure and the residue chromatographed (heptane/EtOAc) to provide the title compound as a white solid.

1. temperaturecooled to room temperature
2. filtrationthe resulting suspension filtered through Celite®
3. washrinsing several times with DCM
4. customThe solvents were removed under reduced pressure
5. customthe residue chromatographed (heptane/EtOAc)