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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 926513Generated: October 26, 2026

5-(4-Fluorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione → 2-(4-Fluorobenzyl)malonic acid

https://huagongshe.com/reaction/926513

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-(4-Fluorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 86096352—
Reactant5-(Benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dioneHCID 86715589—
Reactant2-(Benzo[b]thiophen-2-ylmethyl)malonic acidHCID 86715590—
Product2-(4-Fluorobenzyl)malonic acidHCID 15120643—

Reaction Steps

The title compound was prepared by substituting 5-(benzo[b]thiophen-2-ylmethyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 39: step a) with 5-(4-fluorobenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (Intermediate 42: step a) then following the procedure described for the preparation of 2-(benzo[b]thiophen-2-ylmethyl)malonic acid (Intermediate 39: step b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09284308B2
Source datasetuspto-grants-2016_03
ORD IDord-bbc74e13013c42aeb2d82bdbcb3f4d9a
Source noteuspto-grants-2016_03