HCID 118006037, compound → HCID 118006241, compound

Participants

Reaction Conditions

Reaction Steps

To a 25 mL flask containing (1-methyl-1H-1,2,3-triazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1 g, 3.87 mmol, Intermediate 53: step a) in 1,4-dioxane (10 mL) was added manganese dioxide (2.67 g, 30.65 mmol). The mixture was stirred in an 80° C. oil bath for 2 hours, then cooled to room temperature, diluted with EtOAc and filtered through Celite®. The solvents were removed under reduced pressure and the residue chromatographed (0-100% EtOAc/heptane gradient) to provide the title compound.

Provenance & Evidence