HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hantzsch ester → HCID 178503147, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hantzsch ester | HCID 70849 | — |
| Reactant | 4-(Methylthio)benzaldehyde | HCID 76985 | — |
| Reactant | 6-Bromo-4-hydroxyquinolin-2(1H)-one | HCID 54689446 | — |
| Reactant | (4-Chloro-2-methoxy-3-((6-(trifluoromethyl)pyridin-3-yl)methyl)quinolin-6-yl)(1,2-dimethyl-1H-imidazol-5-yl)methanol | HCID 118005815 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 178503147 | HCID 178503147 | — |
Reaction Steps
A mixture of 4-(methylthio)benzaldehyde (3.00 g, 19.7 mmol), 6-bromo-4-hydroxyquinolin-2(1H)-one (4.72 g, 19.7 mmol, Intermediate 45: step a), diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (5.23 g, 20.7 mmol), and pyridine (100 mL) was stirred at 80° C. for 4 hours and then at room temperature overnight. The reaction was cooled and the formed precipitate was filtered, washed with Et2O (100 mL), and dried to afford the title compound as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284308B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-845dfdbadfec47d8ae0aaff17523b971 |
| Source note | uspto-grants-2016_03 |