反应详情

To a flask containing (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)methanol (1.51 g, 3.1 mmol, Intermediate 81: step a) was added 1,4-dioxane (50 mL) followed by activated manganese dioxide (1.31 g, 15.1 mmol) and the reaction mixture was heated to reflux. After 1 hour, the contents were filtered while still hot through a pad of Celite® and rinsed with THF. The resulting light yellow solution was concentrated and chromatographed on silica gel (10% acetone-hexane increasing to 25% acetone) to provide the title compound as a light yellowish amorphous solid.

1. temperaturethe reaction mixture was heated to reflux
2. filtrationthe contents were filtered while still hot through a pad of Celite®
3. washrinsed with THF
4. concentrationThe resulting light yellow solution was concentrated
5. customchromatographed on silica gel (10% acetone-hexane increasing to 25% acetone)