1-Acetyl-4-(4-fluorobenzoyl)piperidine → HCID 118006290, compound

Participants

Reaction Steps

n-BuLi (1.6 M in THF, 0.26 mL, 0.41 mmol) was added dropwise over a 1 minute period to a mixture of 6-bromo-2,4-bis(difluoromethoxy)-3-(pyrimidin-5-ylmethyl)quinoline (0.16 g, 0.37 mmol, Intermediate 50) and 1-(4-(4-fluorobenzoyl)piperidin-1-yl)ethanone (0.10 g, 0.41 mmol, Intermediate 44) in dry THF (3.8 mL) at −78° C. Stirring was continued at −78° C. for 10 minutes. The reaction mixture was then placed in an ice bath and stirred at 0° C. for 1 hour. The reaction was then quenched with aqueous NH4Cl, diluted with water and extracted with EtOAc (2×). The EtOAc extracts were dried over Na2SO4, filtered, evaporated in vacuo and purified by FCC (0-10% MeOH in DCM, gradient) to provide the title compound. 1H NMR (400 MHz, CDCl3) δ 9.00-9.19 (m, 1H), 8.61-8.79 (m, 2H), 8.05-8.22 (m, 1H), 7.69-7.93 (m, 3H), 7.37-7.56 (m, 2H), 6.93-7.13 (m, 2H), 6.36-6.89 (m, 1H), 4.59-4.83 (m, 1H), 4.20 (s, 2H), 3.67-3.97 (m, 1H), 2.95-3.23 (m, 1H), 2.43-2.83 (m, 2H), 2.04 (s, 3H), 1.61-1.79 (m, 1H), 1.30-1.51 (m, 3H); MS (ESI) 603 [M+H]+.

Provenance & Evidence