Tetrahydrofuran → HCID 118006303, compound

Participants

Reaction Steps

A solution of LaCl3-2LiCl in THF (0.36 mL, 0.22 mmol, 0.6 M in THF) was added to a solution of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-(1-methyl-1H-imidazole-5-carbonyl)quinoline-2,4-dicarbonitrile (50 mg, 0.08 mmol, Intermediate 14: step e) in THF (1.8 mL) at room temperature. After 15 minutes of stirring, a solution of 4-chlorophenyl magnesium bromide (0.32 mL, 0.32 mmol) in diethylether was added dropwise at 0° C. After stirring for 30 minutes, the reaction mixture was quenched with a saturated aqueous solution of NH4Cl and the mixture was partitioned between water and DCM. The layers were separated and the aqueous phase was further extracted with DCM. The organic layers were combined, washed with saturated aqueous NaCl solution, dried (MgSO4), filtered, and concentrated to dryness. The crude product was purified by flash column chromatography (silica gel, 0-7% MeOH-DCM) to provide the title compound. MS m/e 570.3 (M+H)+.

Provenance & Evidence