HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 74220613, compound → HCID 118006547, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 74220613 | HCID 74220613 | — |
| Reactant | 3-(4-(1H-Pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-methylquinoline | HCID 86715598 | — |
| Reactant | (4-Chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(2,6-dimethylpyridin-3-yl)methanol | HCID 86715629 | — |
| Reactant | HCID 118006250 | HCID 118006250 | — |
| Product | HCID 118006547 | HCID 118006547 | — |
Reaction Steps
The title compound was prepared analogously to the method described in Example 78, using 6-bromo-4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinoline (Intermediate 12: step d) in place of 3-(4-(1H-pyrazol-1-yl)benzyl)-6-bromo-2,4-dichloro-8-methylquinoline (Intermediate 57) and (1,2-dimethyl-1H-imidazol-5-yl)(tetrahydro-2H-pyran-4-yl)methanone (Intermediate 31) in place of 1-(4-(6-(trifluoromethyl)nicotinoyl)piperidin-1-yl)ethanone (Intermediate 56: step d). MS m/e 560.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09284308B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-978cabf0170347698d32e3c12c919490 |
| Source note | uspto-grants-2016_03 |