Methanol → HCID 131735019, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (3-benzyl-4-chloro-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol•TFA (84 mg, 0.11 mmol, Example 97) and 0.5 M NaOMe in MeOH (0.80 mL, 0.40 mmol) in a sealed tube was heated at 82° C. for 24 hours. The solvent was evaporated, and the residue was partitioned between EtOAc and water. The organic layer was dried over Na2SO4, filtered, and concentrated. The crude was purified by reverse phase HPLC (water/acetonitrile/0.1% TFA) to provide the title compound as a white solid. 1H NMR (400 MHz, CD3OD) δ 8.96 (s, 1H), 8.61 (d, J=4.04 Hz, 1H), 8.28 (d, J=2.02 Hz, 1H), 8.20 (d, J=9.09 Hz, 1H), 8.00 (dd, J=2.02, 9.09 Hz, 1H), 7.96 (dd, J=2.02, 8.08 Hz, 1H), 7.80 (d, J=8.08 Hz, 1H), 7.39-7.45 (m, 1H), 7.19-7.26 (m, 2H), 7.12-7.18 (m, 1H), 7.09 (d, J=2.02 Hz, 1H), 7.06 (d, J=7.07 Hz, 2H), 4.36 (s, 2H), 3.78 (s, 3H), 3.63 (s, 3H); MS m/e 505.0 [M+H]+.

Provenance & Evidence