Dimethylacetamide → HCID 131735021, compound

Participants

Reaction Conditions

Reaction Steps

A pressure tube containing (3-benzyl-4-chloro-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(pyridin-2-yl)methanol•TFA (86 mg, 0.12 mmol, Example 97), Pd2(dba)3 (10 mg, 0.011 mmol), dicyclohexyl(2′,4′,6′-triisopropyl-[1,1′-biphenyl]-2-yl)phosphine (X-Phos, 10 mg, 0.021 mmol), zinc cyanide (12 mg, 0.10 mmol) and zinc nanopowder (2.3 mg, 0.035 mmol) in N,N-dimethylacetamide (1 mL) was sparged with nitrogen for 8 minutes, and then heated at 120° C. for 2 hours. The mixture was allowed to cool to room temperature, EtOAc and saturated NH4Cl aqueous solution were added. The organic layer was separated, and the aqueous layer was extracted with EtOAc. The combined organic layers were dried (Na2SO4), filtered, and concentrated. The residue was purified by reverse phase HPLC (water/acetonitrile/0.1% TFA) to provide the title compound. 1H NMR (400 MHz, CD3OD) δ 8.98 (s, 1H), 8.62 (d, J=4.04 Hz, 1H), 8.47 (d, J=2.02 Hz, 1H), 8.32 (d, J=9.09 Hz, 1H), 8.17 (dd, J=2.02, 9.09 Hz, 1H), 7.93 (dt, J=2.02, 7.58, 1H), 7.83 (d, J=8.08 Hz, 1H), 7.40-7.45 (m, 1H), 7.24-7.31 (m, 2H), 7.18-7.24 (m, 1H), 7.15 (d, J=1.52, 1H), 7.05 (d, J=7.58 Hz, 2H), 4.64 (s, 2H), 3.63 (s, 3H); MS m/e 500.3 [M+H]+.

Provenance & Evidence