Methanol → HCID 131735024, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (3-benzyl-2,4-dichloroquinolin-6-yl)(1-methyl-1H-imidazol-5-yl)(6-(trifluoromethyl)pyridin-3-yl)methanol (1.10 g, 2.02 mmol, Example 109) and 0.5 M NaOMe in MeOH (13 mL, 6.5 mmol) in a sealed tube was heated at 53° C. for 1 hour. More 0.5 M NaOMe in MeOH (6.5 mL, 3.3 mmol) was added, and the mixture was stirred at the same temperature for another 5 hours. The solvent was evaporated in vacuo, and the residue was diluted with DMF and filtered through a syringe filter. The filtrate was purified by reverse phase HPLC (water/acetonitrile/0.1% TFA) to provide the title compound. 1H NMR (400 MHz, CD3OD) δ 9.03 (s, 1H), 8.83 (d, J=2.02 Hz, 1H), 8.22 (d, J=2.02 Hz, 1H), 8.08 (dd, J=2.02, 8.08 Hz, 1H), 7.92 (d, J=8.59 Hz, 1H), 7.88 (d, J=8.08 Hz, 1H), 7.66 (dd, J=2.27, 8.84 Hz, 1H), 7.22 (d, J=4.04 Hz, 4H), 7.10-7.18 (m, 1H), 7.06 (d, J=1.52 Hz, 1H), 4.28 (s, 2H), 4.07 (s, 3H), 3.71 (s, 3H); MS m/e 539.1 [M+H]+.

Provenance & Evidence