1103508-80-0 → Tepotinib Hydrochloride Hydrate

HRID 926688Notes

Reaction equation

HRID 926688 reaction equation
[ClH:1].[CH3:2][N:3]1[CH2:8][CH2:7][CH:6]([CH2:9][O:10][C:11]2[CH:12]=[N:13][C:14]([C:17]3[CH:18]=[C:19]([CH:36]=[CH:37][CH:38]=3)[CH2:20][N:21]3[C:26](=[O:27])[CH:25]=[CH:24][C:23]([C:28]4[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=4)[C:31]#[N:32])=[N:22]3)=[N:15][CH:16]=2)[CH2:5][CH2:4]1>O>[OH2:10].[ClH:1].[CH3:2][N:3]1[CH2:4][CH2:5][CH:6]([CH2:9][O:10][C:11]2[CH:12]=[N:13][C:14]([C:17]3[CH:18]=[C:19]([CH:36]=[CH:37][CH:38]=3)[CH2:20][N:21]3[C:26](=[O:27])[CH:25]=[CH:24][C:23]([C:28]4[CH:29]=[C:30]([CH:33]=[CH:34][CH:35]=4)[C:31]#[N:32])=[N:22]3)=[N:15][CH:16]=2)[CH2:7][CH2:8]1

Participants

3

Reactant 1

HCID 251716471103508-80-0

Product 1

HCID 46700774Tepotinib Hydrochloride Hydrate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Approx. 50 mg of 3-(1-{3-[5-(1-Methyl-piperidin-4-ylmethoxy)-pyrimidin-2-yl]-benzyl}-6-oxo-1,6-dihydro-pyridazin-3-yl)-benzonitrile hydrochloride anhydrate in its crystalline modification A1 were spread onto a Petri dish and stored in a closed desiccator over pure DI water (100% relative humidity atmosphere) for 3 weeks.

Sources & evidence

ORD record
ord-dce475d211bf41d99d07d25ebdf9b421
Source dataset
uspto-grants-2016_03
Patent number
US09289427B2

Reaction notes

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