N-(1-(5-Fluoropyridin-2-yl)vinyl)acetamide → Acetamide, N-[(1S)-1-(5-fluoro-2-pyridinyl)ethyl]-

Participants

Reaction Conditions

Reaction Steps

10% Pd/C (100 mg) was added to a solution of N-(1-(5-fluoropyridin-2-yl)vinyl)acetamide (440 g, 2.2 mmol) in EtOH (10 mL) and the mixture was stirred continuously under hydrogen atmosphere at 20-35° C. for 1.5 h. The reaction mixture was filtered over a celite bed- and the filtrate was concentrated under reduced pressure to afford 415 g of the title compound as a yellowish brown liquid. MS (ESI): m/z 183 (M+H).

Provenance & Evidence