反应详情

温度

27.5 °C

A mixture of 5N aqueous NaOH solution (5 mL) and N-(1-(5-fluoropyridin-2-yl)ethyl)acetamide (180 mg, 0.4 mmol) was heated under reflux conditions for 12-16 h. After completion of the reaction, the reaction mixture was cooled to a temperature of 20-35° C. The reaction mixture was extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 45 mg of the title compound as a yellow liquid.

1. temperaturewas heated under reflux conditions for 12-16 h
2. customAfter completion of the reaction
3. extractionThe reaction mixture was extracted with DCM
4. dry with materialdried over anhydrous sodium sulphate
5. concentrationconcentrated under reduced pressure