HCID 131732910, compound → HCID 89618415, compound

HRID 926731Notes

Reaction equation

HRID 926731 reaction equation
[OH:1][C@H:2]1[CH2:6][CH2:5][N:4]([CH:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OCC3C=CC=CC=3)[CH2:9][CH2:8]2)[CH2:3]1>CO>[NH2:13][CH:10]1[CH2:9][CH2:8][CH:7]([N:4]2[CH2:5][CH2:6][C@H:2]([OH:1])[CH2:3]2)[CH2:12][CH2:11]1

Participants

3

Reactant 1

HCID 131732910HCID 131732910, compound

Product 1

HCID 89618415HCID 89618415, compoundYield 54,265.699%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
27.5 °C

Procedure

10% vPd/C (40 mg) was added to a solution of (S)-benzyl (4-(3-hydroxypyrrolidin-1-yl)cyclohexyl)carbamate (400 mg, 1.2 mmol) in MeOH (8 mL) and the mixture was stirred continuously under hydrogen atmosphere at 20-35° C. for 15 h. The reaction mixture was filtered over a celite bed and the filtrate was concentrated under reduced pressure to afford 120 g of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered over a celite bed
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e4ffb403f3af4f9e92f95eeca3500587
Source dataset
uspto-grants-2016_03
Patent number
US09289419B2

Reaction notes

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