Methyl morpholine oxide → HCID 89618670, compound

Participants

Reaction Conditions

Reaction Steps

(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridin-3-yl)(3-methyleneazetidin-1-yl)methanone (50 mg, 0.125 mmol) and 4-methylmorpholine N-oxide (44 mg, 0.379 mmol) were dissolved in THF/Water (4:1, 2.0 ml) followed by the addition of Osmium tetroxide (1.38 mg, 0.006 mmol). Reaction mass was stirred for 16 h at 25° C., diluted with ethyl acetate and the organic layer was washed with water, NaOCl solution, followed by brine, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford the title product as brown solid. MS (ESI): m/z 429.7 (M+H).

Provenance & Evidence