HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(difluoromethoxy)-4-fluorobenzene → (R)-2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(difluoromethoxy)-4-fluorobenzene | HCID 24696917 | — |
| Reactant | HCID 89619145 | HCID 89619145 | — |
| Product | (R)-2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidine hydrochloride | HCID 89618672 | — |
Reaction Steps
This compound was prepared by the method substantially similar to the preparation of 2,5-difluorophenyl pyrrolidine hydrochloride as mentioned in Example 1 step 5 using 3-bromo-4-(difluoromethoxy)-1-fluorobenzene (J. Med. Chem. 2003, 46, 1016-1030).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09289419B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-02739c1a462b49b994f153ebab09fd35 |
| Source note | uspto-grants-2016_03 |