(R)-2-(5-fluoro-2-methoxyphenyl)pyrrolidine hydrochloride → (R)-4-fluoro-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxylic acid
Reaction equation
Cl.[F:2][C:3]1[CH:4]=[CH:5][C:6]([O:14][CH3:15])=[C:7]([C@H:9]2[CH2:13][CH2:12][CH2:11][NH:10]2)[CH:8]=1.Br[C:17]1[CH:22]=[CH:21][N:20]2[N:23]=[CH:24][C:25]([C:26]([O:28]CC)=[O:27])=[C:19]2[C:18]=1[F:31]>>[F:31][C:18]1[C:19]2[N:20]([N:23]=[CH:24][C:25]=2[C:26]([OH:28])=[O:27])[CH:21]=[CH:22][C:17]=1[N:10]1[CH2:11][CH2:12][CH2:13][C@@H:9]1[C:7]1[CH:8]=[C:3]([F:2])[CH:4]=[CH:5][C:6]=1[O:14][CH3:15]Participants
3
Procedure
The title compound was prepared by a method substantially similar to that mentioned in step-5 and step-6 of example-3 using (R)-2-(5-Fluoro-2-methoxyphenyl)pyrrolidine hydrochloride (step-1) and Ethyl 5-bromo-4-fluoropyrazolo[1,5-a]pyridine-3-carboxylate (step-4 of example-248) to afford the product as white solid. MS (ESI): m/z 374.12 (M+H).
Sources & evidence
- ORD record
- ord-69c9d609b38549ddb841c21f61644cd8
- Source dataset
- uspto-grants-2016_03
- Patent number
- US09289419B2
Reaction notes
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