Hydrogen chloride-ethyl acetate → N-Palmitoylglycine

Participants

Reaction Steps

To N-palmitoyl-Gly-OtBu (17.4 g, 47.1 mmol), 4M HCl/AcOEt (118 ml, 0.471 mmol) was added and the whole was stirred at room temperature for 1 hour. After concentration under reduced pressure, the residue was washed with hexane to give 11.4 g (77%) of a target compound as colorless powder.

Provenance & Evidence