反应详情

4-(4-nitrophenyl)butanol (compound 19, 1.7 mL, 10.2 mmol) was dissolved in methanol (20 mL) to which 10% Palladium on carbon (0.2 g) was added and the mixture was hydrogenated using hydrogen gas (30 psi) at ambient temperature for 1 hr. The mixture was filtered through celite filter aid and solvent was evaporated from the filtrate under vacuum to give 1.3 g (77% yield) of crude product. Mass spectrum (M+H)+ calcd for C10H15NO 166.1. found 166.1.

1. additionwas added
2. customat ambient temperature
3. customfor 1 hr
4. filtrationThe mixture was filtered through celite
5. filtrationfilter aid and solvent
6. customwas evaporated from the filtrate under vacuum