Cycloheptylamine → HCID 86646400, compound

HRID 926899Notes

Reaction equation

HRID 926899 reaction equation
[CH:1]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Br-:9].C([N+]1[CH:18]=[CH:17][N:16]([CH2:19][CH:20]([CH3:22])C)[CH:15]=1)C(C)C>>[Br-:9].[CH:1]1([N+:8]2[CH:18]=[CH:17][N:16]([CH:19]3[CH2:20][CH2:22][CH2:3][CH2:2][CH2:1][CH2:7]3)[CH:15]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2899CycloheptylamineHCID 12982421HCID 12982421, compound

Product 1

HCID 86646400HCID 86646400, compoundYield 63%

Procedure

Using cycloheptylamine (2×110.4 mmol) the procedure used in Example 1 for synthesizing compound 1 was followed yielding 23.60 g white solids after drying under high vacuum (69.1 mmol, 63% yield). 1H NMR (300 MHz, DMSO-d6): 9.44, 7.93, 4.50, 2.08-1.97, 1.95-1.97, 1.77-1.69, 1.65-1.56, 1.54-1.46. 13C NMR (75 MHz, DMSO-d6): 133.5, 120.8, 61.1, 34.7, 26.8, 23.3. Analysis calculated for C17H29BrN2: C, 59.82; H, 8.56; N, 8.21 (C/N=7.29). Found: C, 59.45; H, 8.33; N, 8.08 (C/N=7.36).

Sources & evidence

ORD record
ord-706adaa25158488f91a7d6dcf571eae8
Source dataset
uspto-grants-2016_03
Patent number
US09289757B2

Reaction notes

Loading…