HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Butenedioic acid, monoethyl ester → (E)-ethyl 4-(2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamidoethylamino)-4-oxobut-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Butenedioic acid, monoethyl ester | HCID 5878225 | — |
| Reactant | (E)-methyl 4-(2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamidoethylamino)-4-oxobut-2-enoate | HCID 53255264 | — |
| Product | (E)-ethyl 4-(2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamidoethylamino)-4-oxobut-2-enoate | HCID 53340288 | — |
Reaction Steps
Mono ethyl fumarate (commercially available) was subjected to the same reaction conditions outlined earlier in the preparation of (E)-methyl 4-(2-(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamidoethylamino)-4-oxobut-2-enoate. The desired product, namely (E)-ethyl 4-(2-(4Z,7Z,10Z,13Z,16Z,19Z) -docosa-4,7,10,13,16,19-hexaenamidoethylamino)-4-oxobut-2-enoate, was obtained after purification by silica gel chromatography. MS (EI) calcd for C30H40N2O4: 496.33; found 497 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09289503B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-96a9d6b463e34d2cbe83470155b5656e |
| Source note | uspto-grants-2016_03 |