Chloromethyl Methyl Ether → HCID 88909600, compound

Participants

Reaction Steps

Compound 2 (4 g, 10.42 mmol) was dissolved in N,N-diisopropylethylamine (DIPEA, 20 mL) freshly distilled over calcium hydride. The solution was cooled in an ice-bath and the chloromethyl methyl ether (4.75 mL, 62.5 mmol) was added. A white precipitate appeared instantaneously. The reaction mixture was stirred overnight at room temperature. After removal of DIPEA under vacuum, the residue was chromatographied over silica gel using heptane/acetone (97/3) to give 4.23 g (9.89 mmol, 95% yield) of a slightly yellow solid.

Provenance & Evidence