HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 926923Generated: November 2, 2026
N-bromobutanimide → 1-Bromo-5-methyl-3,3-bis(trifluoromethyl)-1,3-dihydro-1lambda3,2-benziodoxole
https://huagongshe.com/reaction/926923
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1,1,1,3,3,3-Hexafluoro-2-(2-iodo-5-methylphenyl)propan-2-ol | HCID 329555 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 1-Bromo-5-methyl-3,3-bis(trifluoromethyl)-1,3-dihydro-1lambda3,2-benziodoxole | HCID 326933 | 100% |
Reaction Steps
Compound 2 (100 mg, 0.26 mmol) was dissolved in 5 mL propan-2-ol and N-bromosuccinimide (48.7 mg, 0.273 mmol) is added. The reaction mixture was heated 30 min at 50° C. After removal of the solvent under vacuum, the residue was purified over silica gel column using dichloromethane as eluant to give 111 mg (0.26 mmol, 92% yield) of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09290421B2 |
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| Source dataset | uspto-grants-2016_03 |
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| ORD ID | ord-335ffb6bbc2e4a95ae944d9ab678d386 |
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| Source note | uspto-grants-2016_03 |
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