Hydrochloric Acid → 1-Chloro-5-methyl-3,3-bis(trifluoromethyl)-1,3-dihydro-1lambda3,2-benziodoxole

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Reaction Steps

Compound 2 (60 mg, 156 μmol) was dissolved in 2 mL propan-2-ol, 10 μL hydrochloric acid (37%) and 50 μL sodium hypochlorite solution (10-15% in water) were added. A white precipitate appeared instantaneously. The reaction mixture was stirred 5 min at room temperature. The solvent was removed under vacuum and the residue was purified over silica gel column using dichloromethane as eluant to give 50 mg (119 μmol, 76% yield) of a white solid.

Provenance & Evidence