HCID 87357812, compound → HCID 87358663, compound

Participants

Reaction Conditions

Reaction Steps

Compound 7 (622 mg, 906 μmol) was dissolved in dichloromethane (10 mL) and the solution was degassed by nitrogen bubbling over 15 min. The solution was then added to N,N-dimethylbarbituric acid (849 mg, 5.44 mmol) and Tetrakis(triphenylphosphine)palladium(0) (21 mg 18.1 μmol) placed in a two necked flask under nitrogen atmosphere and the resulting mixture was warmed 4 h at 35° C. The solvent was removed under vacuum, the residue dissolved in diethylether (20 mL), and washed with a 0.1M sodium carbonate solution (3×10 mL). The organic layer was dried over sodium sulfate and concentrated under vacuum. The residue was purified over silica gel using dichloromethane/methanol (95/5) to give 423 mg (698 μmol, 77% yield) of a yellowish oil.

Provenance & Evidence