反应详情

Chloromethyl phenyl sulfoxide (200 mg, 1.29 mmol) of example 21 was dissolved in dry diethyl ether (7.5 mL) under an argon atmosphere. tert-Butyl benzene (0.191 g, 1.1 eq) was added to the previous solution and then the mixture was cooled to a temperature below −60° C. After stabilizing the temperature, trifluoromethanesulfonic anhydride (0.217 mL, 1 eq) was added slowly maintaining the same temperature. The mixture was stirred until the reaction was complete. The orange precipitated triflate salt was quickly filtered at −60° C. affording 0.487 g as red viscous oil after heating at room temperature, which was a mixture by proton NMR.

1. temperaturethe mixture was cooled to a temperature below −60° C
2. additionwas added slowly
3. temperaturemaintaining the same temperature
4. customThe orange precipitated triflate salt
5. filtrationwas quickly filtered at −60° C.
6. customaffording 0.487 g as red viscous oil