反应详情

温度

-40 °C

Methyl phenyl sulfoxide (21.644 g, 154.4 mmol) was dissolved in anhydrous pyridine (27.4 mL, 2.2 eq) and dry acetonitrile (100 mL). The solution was cooled to −40° C. under an argon atmosphere. A solution of bromine (49.4 g, 2 eq) in dry acetonitrile (50 mL) was added slowly, maintaining the same temperature. The mixture was stirred at −40° C. for 1 h and then overnight at room temperature. The solvent was evaporated under vacuum and the residue was dissolved in dichloromethane. The organic layer was washed with Na2S2O3 20%, dried over anhydrous Na2SO4 and concentrated to dryness.

1. temperaturemaintaining the same temperature
2. customovernight
3. customat room temperature
4. customThe solvent was evaporated under vacuum
5. dissolutionthe residue was dissolved in dichloromethane
6. washThe organic layer was washed with Na2S2O3 20%
7. dry with materialdried over anhydrous Na2SO4
8. concentrationconcentrated to dryness