HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Leucinol → 3,6-Diisobutylhexahydropyrazine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Leucinol | HCID 111307 | — |
| Catalyst | Ruthenium | HCID 23950 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3,6-Diisobutylhexahydropyrazine-2,5-dione | HCID 137006 | — |
Reaction Steps
Refluxing a dioxane solution of (S)-2-amino-4-methylpentan-1-ol with complex 1 (1 mol %) led to 64% isolated yield of the cyclic dipeptide, 3,6-diisobutylpiperazine-2,5-dione 7b after workup (Table 9, entry 1). The product structure was confirmed by MS, NMR spectroscopies.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290441B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-f69790c66fed489d94215120793426c2 |
| Source note | uspto-grants-2016_03 |