US9290457, Example 1.5 → US9290457, Example 7

Participants

Reaction Steps

2-[5-Acetyl-3,6-dimethyl-2-oxo-1-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-pyrimidin-4-yl]-5-cyano-N-prop-2-ynyl-benzamide (intermediate 12) (48 mg, 0.097 mmol) is suspended in dichloromethane (2 mL) and degassed with a stream of argon. gold(III)-chloride (1.2 mg, 0.004 mmol) is added and the reaction is shaken at room temperature for 2 h. The solvent is evaporated and the residue is purified by reversed phase HPLC. Yield: 17 mg; ESI mass spectrum [M+H]+=495; Retention time HPLC: 1.09 min (HPLC method Z011_S03).

Provenance & Evidence