Trifluoroacetic acid → HCID 118691689, compound

Participants

Reaction Steps

4-{2-[5-Acetyl-3,6-dimethyl-2-oxo-1-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-pyrimidin-4-yl]-5-cyano-phenyl}-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (example 5.6) (35 mg, 0.06 mmol) is suspended with aqueous trifluoroacetic acid (95%, 2 mL). The reaction mixture is shaken for 15 min, evaporated and the product is purified by reversed phase HPLC. Yield: 25 mg; ESI mass spectrum [M+H]+=495; Retention time HPLC: 1.20 min (HPLC method Z018_S04).

Provenance & Evidence