HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 67984621, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (1R)-1-(4-chlorophenyl)ethan-1-amine | HCID 1715226 | — |
| Reactant | 2-Amino-5-bromo-3-pyridinecarbaldehyde | HCID 24213792 | — |
| Reactant | 7-(4-Fluorophenyl)-7-oxoheptanoic acid | HCID 24726875 | — |
| Reactant | TFAA tBuOH | HCID 86701127 | — |
| Product | HCID 67984621 | HCID 67984621 | — |
Reaction Steps
In a manner similar to that described previously (Example 1), 2-amino-5-bromopyridine-3-carboxaldehyde was sequentially reacted with 7-(4-fluorophenyl)-7-oxoheptanoic acid and TFAA-tBuOH. The resulting ester 6B was converted to 6C, coupled with (R)-1-(4-chlorophenyl)ethanamine, and deprotected with TFA to provide the title compound, 6-[[[1(R)-(4-chlorophenyl)ethyl]amino]carbonyl]-2-(4-fluorophenyl)-1,8-naphthyridine-3-pentanoic acid, 6. LCMS (M+H)=506.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09290453B2 |
| Source dataset | uspto-grants-2016_03 |
| ORD ID | ord-7d468b9cc720462db67eb16e5b11fb20 |
| Source note | uspto-grants-2016_03 |