Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butanol | HCID 6386 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Reactant | HCID 90203448 | HCID 90203448 | — |
| Product | HCID 90203276 | HCID 90203276 | 33% |
Reaction Steps
A solution of 3-(4-cyano-phenyl)-isoxazole-4-carboxylic acid (4.7 g, 22 mmol) in tert-butanol was treated with diphenylphosphoryl azide (5.1 mL, 24 mmol) and triethylamine (3.33 mL, 24 mmol). The solution was heated to 80° C. for 14 h and then all volatiles were removed under reduced pressure to give [3-(4-cyano-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester (2.1 g, 33%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09290465B2 |
|---|
| Source dataset | uspto-grants-2016_03 |
|---|
| ORD ID | ord-65f0105e14ee4005a24181f451e977a7 |
|---|
| Source note | uspto-grants-2016_03 |
|---|
