Triethylamine → HCID 90203830, compound

Participants

Reaction Steps

To a solution of (3-{4-[(Z)-2-(4-Methanesulfonyl-phenyl)-vinyl]-phenyl}-isoxazol-4-yl)-carbamic acid tert-butyl ester (220 mg, 0.5 mmol) in CH2Cl2 (2 mL) was added triethylamine (0.7 mL, 5 mmol) and 2-nitrobenzenesulfhydrazide (1.0 g, 4.6 mmol). The reaction mixture was stirred for 24 h at rt and then washed with satd NaHCO3 and dried over Na2SO4. Filtration was followed by removal of volatiles over silica gel followed by column chromatography to yield (3-{4-[2-(4-methanesulfonyl-phenyl)-ethyl]-phenyl}-isoxazol-4-yl)-carbamic acid tert-butyl ester (88 mg, 40%) as a white solid.

Provenance & Evidence