2-Phenylethanol → HCID 90203155, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [3-(4-hydroxy-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester (68 mg, 0.247 mmol), phenethyl alcohol (30 μL, 0.25 mmol)) and triphenylphosphine (136 mg, 0.52 mmol) in THF (1.5 mL) at 0° C. was added diethylazodicarboxylate (100 μL, 0.55 mmol) over 1.5 h. The reaction mixture was warmed to 90° C. for 62 h and cooled to rt. Volatiles were removed under reduced pressure and the crude product was dry-loaded onto silica gel. Chromatography provided [3-(5-phenethyloxy-pyridin-2-yl)-isoxazol-4-yl]-carbamic acid tert-butyl ester (60 mg, 64%).

Provenance & Evidence