Ethyl Acetate → HCID 90203479, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of [3-(4-hydroxy-phenyl)-isoxazol-4-yl]-carbamic acid tert-butyl ester (38 mg, 0.137 mmol) in DMF (1 mL) was added K2CO3 (20 mg, 0.145 mmol) and 3-phenyl-1-bromopropane (20 μL, 0.132 mmol). After stirring for 1 h at rt and 14 h at 50° C., the reaction mixture was cooled stirred for 6 h at rt. The reaction mixture was loaded directly onto silica gel. {3-[4-(3-Phenyl-propoxy)-phenyl]-isoxazol-4-yl}-carbamic acid tert-butyl ester was isolated as a white solid by column chromatography (10% ethyl acetate in hexane).

Provenance & Evidence