Hydrochloric Acid → HCID 76071676, compound

Participants

Reaction Steps

{3-[4-(3-Phenyl-propoxy)-phenyl]-isoxazol-4-yl}-carbamic acid tert-butyl ester (54 mg, 0.137 mmol) was dissolved in dioxane (9 mL) and treated with conc. HCl (1.5 mL). After stirring for 12 h at rt the reaction mixture was quenched with 10 mL of satd aqueous NaHCO3. The organic layer was separated and dried over Na2SO4. Filtration followed by removal of volatiles under reduce d pressure gave crude product. 3-[4-(3-Phenyl-propoxy)-phenyl]-isoxazol-4-ylamine (22 mg, 55%) was isolated as a white solid by column chromatography (30% ethyl acetate in hexanes). HRMS: 295.144 (M+1).

Provenance & Evidence