Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927059Generated: October 26, 2026

1-Ethynyl-4-fluorobenzene → 3,4-bis(Benzyloxy)-6-[(4-fluorophenyl)ethynyl]pyridazine

https://huagongshe.com/reaction/927059

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Ethynyl-4-fluorobenzeneHCID 522627—
Reactant3,4-Bis(benzyloxy)-6-chloropyridazineHCID 12213474—
Reactant3,4-Bis(benzyloxy)-6-(phenylethynyl)pyridazineHCID 71270419—
Product3,4-bis(Benzyloxy)-6-[(4-fluorophenyl)ethynyl]pyridazineHCID 7127024172%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-(phenylethynyl)pyridazine (Intermediate 2) from 3,4-bis(benzyloxy)-6-chloropyridazine (Intermediate 1) and 1-ethynyl-4-fluorobenzene in 72% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-c867f7a1e1f94503b6e8d04243a0795d
Source noteuspto-grants-2016_03