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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927069Generated: October 26, 2026

Benzene, 1-iodo-3-(trifluoromethyl)- → 3,4-Bis(benzyloxy)-6-{2-[3-(trifluoromethyl)phenyl]ethynyl}pyridazine

https://huagongshe.com/reaction/927069

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 1-iodo-3-(trifluoromethyl)-HCID 67868—
Reactant3,4-Bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazineHCID 71270134—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-Bis(benzyloxy)-6-{2-[3-(trifluoromethyl)phenyl]ethynyl}pyridazineHCID 71270335—

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazine (Intermediate 9) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 1-iodo-3-(trifluoromethyl)benzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-4354c21cd2ae415eb42651ec178054b4
Source noteuspto-grants-2016_03