Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927070Generated: October 26, 2026

3-Bromo-5-(trifluoromethyl)pyridine → 3,4-bis(Benzyloxy)-6-{2-[5-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazine

https://huagongshe.com/reaction/927070

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-5-(trifluoromethyl)pyridineHCID 11127991—
Reactant3,4-Bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazineHCID 71270134—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-bis(Benzyloxy)-6-{2-[5-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazineHCID 71270353—

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazine (Intermediate 9) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 3-bromo-5-trifluoromethylpyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-d002847c55de4b8aab33c99ee210018c
Source noteuspto-grants-2016_03