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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927075Generated: October 26, 2026

3-Bromo-5-(difluoromethyl)pyridine → 3,4-Bis(benzyloxy)-6-[(3-(difluoromethyl)phenyl)ethynyl]pyridazine

https://huagongshe.com/reaction/927075

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Bromo-5-(difluoromethyl)pyridineHCID 640480—
Reactant3,4-Bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazineHCID 71270134—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-Bis(benzyloxy)-6-[(3-(difluoromethyl)phenyl)ethynyl]pyridazineHCID 71270039—

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[6-(trifluoromethyl)pyridin-3-yl]ethynyl}pyridazine (Intermediate 9) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 3-bromo-5-difluoromethylpyridine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-8df6417d525946388f2a8750440a778c
Source noteuspto-grants-2016_03