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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927080Generated: October 27, 2026

4-Iodobenzonitrile → 4-{2-[5,6-bis(Benzyloxy)pyridazin-3-yl]ethynyl}benzonitrile

https://huagongshe.com/reaction/927080

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-IodobenzonitrileHCID 76467—
Reactant3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazineHCID 71269910—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product4-{2-[5,6-bis(Benzyloxy)pyridazin-3-yl]ethynyl}benzonitrileHCID 7127055073%

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 4-iodobenzonitrile in 73% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-c4e6fb6f0cc340d99278c736564497d3
Source noteuspto-grants-2016_03