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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 927085Generated: October 26, 2026

1-Bromo-2,6-difluorobenzene → 3,4-bis(Benzyloxy)-6-[2-(2,6-difluorophenyl)ethynyl]pyridazine

https://huagongshe.com/reaction/927085

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Bromo-2,6-difluorobenzeneHCID 123557—
Reactant3,4-Bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazineHCID 71269910—
Reactant3,4-Bis(benzyloxy)-6-ethynylpyridazineHCID 86677025—
Product3,4-bis(Benzyloxy)-6-[2-(2,6-difluorophenyl)ethynyl]pyridazineHCID 71270075—

Reaction Steps

Prepared as described for 3,4-bis(benzyloxy)-6-{[5-(trifluoromethyl)pyridin-2-yl]ethynyl}pyridazine (Intermediate 6) from 3,4-bis(benzyloxy)-6-ethynylpyridazine (Intermediate 5) and 2-bromo-1,3-difluorobenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09290456B2
Source datasetuspto-grants-2016_03
ORD IDord-2fe6617acc044d4f919cfc781b62a1c8
Source noteuspto-grants-2016_03